Publicaciones (Departamento de Genética)
2025
García-Martínez OI, Geisinger A, de los Santos E, Santiñaque FF, Folle GA, Pórfido J, Meikle MN, Schlapp G, Crispo M, BenaventeR & Rodríguez-Casuriaga R (2025).Mouse modeling of familial human SYCE1 c.197-2A>G splice site mutation leads to meiotic recombination failure and non-obstructive azoospermia. Mol Hum Reprod.
Alem D, García-Laviña CX, Garagorry F, Centurión D, Farias J, Pazos-Espinosa H, Cuitiño-Mendiberry MN, Villadóniga C, Castro-Sowinski S, Fló M, Carrión F, Iglesias B, Madauss K, Canclini L (2025). Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage. Scientific Reports.
Cancela S, Minini L, Mourglia-Ettlin G, Merlino A, Lavaggi ML, Hernández P (2025). Novel thiazole-nitrone hybrids as innovative neuroprotective agents with antioxidant and antiapoptotic properties. Results in Chemistry.
Mila R, Hernández F, Cordon JJ, Durán A, Martínez-López W (2025). Retrospective Study of Radiation Exposures during Interventional Cardiology Procedures Performed at the University Cardiovascular Center of Uruguay. Radiology & Imaging.
2024
Romeo-Cardeillac C, Trovero MF, Radío S, Smircich P, Rodríguez-Casuriaga R, Geisinger A*, & Sotelo-Silveira J*. Uncovering a multitude of stage-specific splice variants and putative protein isoforms generated along mouse spermatogenesis. BMC Genomics. (*co-corresponding authors).
Reyes-Ábalos, A. L., Álvarez-Zabaleta, M., Olivera-Bravo, S., & Di Tomaso, M. V. (2024). Astrocyte DNA damage and response upon acute exposure to ethanol and corticosterone. Frontiers in Toxicology, 5, 1277047.
Reyes-Ábalos, A. L., Álvarez-Zabaleta, M., Olivera-Bravo, S. & Di Tomaso, M. V. (2024). Acute Genetic Damage Induced by Ethanol and Corticosterone Seems to Modulate Hippocampal Astrocyte Signaling. International Journal of Cell Biology, 2024(1), 5524487.
Anzibar Fialho, M., Martínez Barreiro, M., Vázquez Alberdi, L., Calero, M., Di Tomaso, M. V., Baranger, J., Tanter, M., Negreira, C., Rubido, N., Kun, A., & Brum, J. (2024). Functional ultrasound and brain connectivity reveal central nervous system compromise in Trembler-J mice, model of Charcot-Marie-Tooth disease. Scientific Reports.
Mila, R., Hernández, F., Cordon, J. J., Durán A. & Martínez-López, W. (2024). Retrospective study of radiation exposures during interventional cardiology procedures performed at the University Cardiovascular Center of Uruguay. Brazillian Journal of Radiation Sciences, en prensa.
González Mesa, J. E., Alem, D., Valle Bourrouet, L., Chaves Campos, F. A., Ortiz Morales, F., Rodríguez González, M., Abarca Ramírez, M., Verdejo, V., Di Giorgio, M., Radl, A., Taja, M. R., Deminge, M., Rada-Tarifa, A., Lafuente-Álvarez, E., Farías de Lima, F., Hwang, S., Esposito Mendes, M., Mandina-Cardoso, T., Muñoz-Velastegui, G., Guerrero-Carbajal, Y. C., Arceo Maldonado, C., Monjagata, N., Aguilar-Coronel, S., Espinoza, M. E., Falcon de Vargas, A., Di Tomaso, M. V., Holladay, B., García Lima, O. & Martínez-López, W. (2024). LBDNet interlaboratory comparison for digitized image analysis of the dicentric chromosome assay and the application of differential weights for dose estimation. International Journal of Radiation Biology, 100(7):1019-1028.
Ikeda Kawasaki, J. A., Lucas Pinheiro, L. C., da Silva, I. M., Miqueloto, C. A., Brajão de Oliveira, K., Ribeiro, D. L., Losi Guembarovski, A. F. S., Terziotti, F., Martínez-López, W., Serpeloni, J. M. & Losi Guembarovski, R. (2024). BCL-2 and γ-H2AX immunostaining profile in urothelial bladder cancer prognosis. Pathology-Research and Practice, 264.
Pootheri, A., Martínez-López, W., Saraswathy, R. (2024). A case-control study on asthma and obese patients: Influence of lifestyle patterns, serum trace elements, heavy metals, and total antioxidants. Heliyon, 10, e29270.
2023
Hochmann, J., Millán, M., Hernández, P., Lafon-Hughes, L., Aiuto, N., Silva, A., Llaguno, J., Alonso, J., Fernández, A., Pereira-Prado, V., Sotelo-Silveira, J., Bologna-Molina, R. & Arocena, M. (2023). Contributions of viral oncogenes of HPV-18 and hypoxia to oxidative stress and genetic damage in human keratinocytes. Scientific Reports.
Ruatta, S. M., Prada Gori, D. N., Fló Díaz, M., Lorenzelli, F., Perelmuter, K., Alberca, L. N., Bellera, C. L., Medeiros, A., López, G. V., Ingold, M., Porcal, W., Dibello, E., Ihnatenko, I., Kunick, C., Incerti, M., Luzardo, M., Colobbio, M., Ramos, J. C., Manta, E., Minini, L., Lavaggi, M. L., Hernández, P., Šarlauskas, J., Huerta García, C. S., Castillo, R., Hernández-Campos, A., Ribaudo, G., Zagotto, G., Carlucci, R., Medrán, N. S., Labadie, G. R., Martínez-Amezaga, M., Delpiccolo, C. M. L., Mata, E. G., Scarone, L., Posada, L., Serra, G., Calogeropoulou, T., Prousis, K., Detsi, A., Cabrera, M., Álvarez, G., Aicardo, A., Araújo, V., Chavarría, C., Mašič, L. P., Gantner, M. E., Llanos, M. A., Rodríguez, S., Gavernet, L., Park, S., Heo, J., Lee, H., Paul Park, K. H., Bollati-Fogolín, M., Pritsch, O., Shum, D., Talevi, A., & Comini, M. A. (2023). Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro. Frontiers in Pharmacology.
Varela, M., López, M., Ingold, M., Alem, D., Perini, V., Perelmuter, K., Bollati-Fogolín, M., López, G. V. & Hernández, P. (2023). New Nitric Oxide-Releasing Compounds as Promising Anti-Bladder Cancer Drugs. Biomedicines.
Ronco, A. L., Martínez-López, W., Calderón, J. M., Mintegui, G. & Storz, M. A. (2023). Dietary acid load and risk of cancer: new insights from a nationwide case-control study. World Cancer Research Journal, 10, e2547.
Ronco A. L., Martínez-López W., Calderón J. M. & Storz M. A. (2023) Dietary acid load and risk of head and neck and oral cavity cancers: An epidemiologic study. Oral Science International.
Keuchkerian, R., Suescun, L., Crisci, C., Aguiar, I., Martínez-López, W., Pérez Barthaburu, M. E. & Rodríguez Chialanza, M. (2023). Optimization of solvothermal experimental parameters to control the size of KMgF3 nanoparticles for photodynamic therapy. Applied Nanoscience. 2023 Jun 12:1-9.
Jansen van Vuuren, A., Bolcaen, J., Engelbrecht, M., Burger, W., De Kock, M., Durante, M., Fisher, R., Martínez-López, W., Miles, X., Rahiman, F., Tinganelli, W. & Vandevoorde, C. (2023). Establishment of Primary Adult Skin Fibroblast Cell Lines from African Savanna Elephants (Loxodonta africana). Animals, 13, 2353.
Mila, R., Hernandez, F., Cordon, J. J., Duran, A. & Martínez-López, W. (2023). Retrospective study of radiation exposures during interventional cardiology procedures performed at the University Cardiovascular Center of Uruguay. Brazilian Journal of Radiation Sciences.
2022
Acosta, S., Canclini, L., Marizcurrena, J. J., Castro-Sowinski, S. & Hernández, P. (2022). Photo-repair effect of a bacterial Antarctic CPD-photolyase on UVC-induced DNA lesions in human keratinocytes. Environ Toxicol Pharmacol. doi:10.1016/j.etap.2022.104001
Di Tomaso, M. V., Vázquez Alberdi, L., Olsson, D., Cancela, S., Fernández, A., Rosillo, J. C., Calero, M. & Kun, A. (2022). Colocalization analysis of peripheral myelin protein-22 and lamin-B1 in the Schwann cell nuclei of Wt and TrJ mice. Biomolecules, 12(3), 456. doi: 10.3390/biom12030456
Vázquez Alberdi, L.; Rosso, G.; Velóz, L.; Romeo, C.; Farias, J.; Di Tomaso, M. V. & Kun, A. (2022). Curcumin and ethanol effects in trembler-J Schwann cell culture. Biomolecules, 12(4), 515. doi: 10.3390/biom12040515.
Ronco, A. L., Martínez-López, W., Calderón, J. M. & Storz, M. A. (2022). Dietary acid load and esophageal cancer risk: A case-control study. Thoracic Cancer. doi: 10.1111/1759-7714.14612.
Low, G. K. M., Ting, A. P. L., Fok, E. D. Z., Gopalakrishnan, K., Zeegers, D., Khaw, A. K., Jayapal, M., Martínez-López, W. & Hande, M. P. (2022). Role of Xeroderma pigmentosum D (XPD) protein in genome maintenance in human cells under oxidative stress. Mutation Research: Genetic Toxicology and Environmental Mutagenesis. doi: 10.1016/j.mrgentox.2022.503444.
Joshua, P., Shivaram, A., Panchami, P., Patel, B., Jaikrishnan, D., Martínez-López, W. & Saraswathy, R. (2022). Awareness of Mobile Phone Radiation and Its Potential Health Hazards Among Students and Working-class Population During the COVID-19 Pandemic: A Cross-sectional Survey. Advanced Journal of Graduate Research. doi: https://doi.org/10.21467/ajgr.12.1.1-10
Alem, D., Canclini, L., Castro-Sowinski, S. & Martínez-López, W. (2022). Chemosensitizer Effect of Violacein on Cisplatin-treated Bladder Cancer Cells. Clinical Complementary Medicine and Pharmacology 2, 1-9. doi.org/10.1016/j.ccmp.2022.100036
Olivera‐Bravo S, Bolatto C, Otero Damianovich G, Stancov M, Cerri S, Rodríguez P, Boragno D, Hernández Mir K, Cuitiño MN, Larrambembere F, Isasi E, Alem D, Canclini L, Marco M, Davyt D, Díaz‐Amarilla P. (2022). Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis. Scientific Reports.
Pootheri, A., Martínez-López, W. & Saraswathy, R. (2022). Action of Reactive Oxygen Species in Metabolic Diseases employed as Biomarkers of Oxidative Stress. Research Journal of Biotechnology. 17:207-215.
Ingold, M., de la Sovera, V., Dapueto, R., Hernández, P., Porcal, W. & López, G. V. (2022). Greener Synthesis of Antiproliferative Furoxans via Multicomponent Reactions. Molecules. doi:10.3390/molecules27061756
Lafón, L. (2022). Poly(ADP-ribose), adherens junctions, vinculin and the actin cytoskeleton: current evidence, future perspectives and implications. Biocell. https://doi.org/10.32604/biocell.2022.022713
Prarthana Srikanth, Amit Roy Chowdhury, Grace Kah Mun Low, Radha Saraswathy, Akira Fujimori, Birendranath Banerjee, Wilner Martinez-Lopez & M. Prakash Hande (2022). Oxidative Damage Induced Telomere Mediated Genomic Instability in Cells from Ataxia Telangiectasia Patients. Genome Integrity.
2021
Damián, J. P., Vázquez Alberdi, L., Canclini, L., Rosso, G., Bravo, S. O., Martínez, M., Uruarte, N., Ruiz, P., Calero, M., Di Tomaso, M. V. & Kun, A. (2021). Central alteration in peripheral neuropathy of Trembler-J mice: Hippocampal pmp22 expression and behavioral profile in anxiety tests. Biomolecules, 11(4), 601.
Vilchez Larrea, S., Valsecchi, W. M., Fernández Villamil, S. H. (*), Lafon Hughes, L. (*). (2021). First body of evidence suggesting a role of a tankyrase-binding motif (TBM) of vinculin (VCL) in epithelial cells. PeerJ 9:e11442 https://doi.org/10.7717/peerj.11442
Lafon-Hughes, L., Fernández Villamil, S. (*) & Vilchez Larrea, S. (*). (2021). Tankyrase inhibitors hinder Trypanosoma cruzi infection by altering host-cell signalling pathways. Parasitology, 148 (13), 1680-1690. doi:10.1017/S0031182021001402
Acosta, S., Canclini, L., Galarraga, C., Justet, C. & Alem, D. (2021). Lab-made 3D printed stoppers as high-throughput cell migration screening tool. SLAS Technology, in press.
Tuttis, K., Maldonado Gomes da Costa, D. L., Serpeloni, J. M., Campaner dos Santos, L., Varanda, E. A., Wagner, V., Martínez-López, W. & de Syllos Colus, I. M. (2021). Phytochemical Profile, and Antiproliferative and Proapoptotic Effects of Pouteria ramiflora (Mart.) Radlk. Leaf Extract, and Its Synergism with Cisplatin in HepG2 Cells. Journal of Medicinal Food 24:1-12. https://doi.org/10.1089/jmf.2020.0045.
Rajagopalan, A., Martínez-López, W. & Saraswathy, R. (2021). Cardiovascular Complications during COVID-19 Infection. Review Article J Clin Toxicol. 11. 473.
Ronco, A. L., Martínez-López, W., Mendoza, B. & Calderón, J. M. (2021). Epidemiologic Evidence for Association between a High Dietary Acid Load and the Breast Cancer Risk (2021). Sci Medicine Journal, 3(2): 166-176. doi: 10.28991/SciMedJ-2021-0302-8
Hande, V., Teo, K., Srikanth, P., Wong, J. S. M., Sethu, S., Martínez-López, W. & Hande, M. P. (2021). Investigations on the new mechanism of action for acetaldehyde-induced clastogenic effects in human lung fibroblasts. Mutation Research. Jan-Feb, 861-862:503303. doi: 10.1016/j.mrgentox.2020.503303.
Ronco, A. L., Martínez-López, W., Calderón, J. M. & Golomar, W. (2021). Dietary acid load and lung cancer risk: A case-control study in men. Cancer Treatment and Research Communications. 28:100382. doi: 10.1016/j.ctarc.2021.100382.
Serpeloni, J. M., Tuttis, K., Leal Specian, A. F., Ribeiro, D. L., Martínez-López, W., Heredia-Vieira, S. C., Vilegas, W., Varanda, E. A. & de Syllos Colus, I. M. (2021). Selective anticancer effects of Serjania marginata Casar. Extract in gastric cells are mediated by antioxidant response. Environmental Toxicology, 36:1544-1556. doi: 10.1002/tox.23151.
Ronco, A. L., Storz, M. A., Martínez-López, W., Calderón, J. M. & Golomar, W. (2021). Dietary acid load and risk of kidney cancer: an epidemiologic case-control study. World Cancer Research Journal, 8:e2096. DOI: 10.32113/wcrj_20219_2096.
Ronco, A. L., Storz, M. A., Martínez-López, W., Calderón, J. M. & Golomar, W. (2021). High dietary acid load is associated with prostate cancer risk: An epidemiological study. World Cancer Research Journal, 8:e2119. DOI: 10.32113/wcrj_202111_2119.
Nair, S., Cairncross, S., Miles, X., Engelbrecht, M., du Plessis, P., Bolcaen, J., Fisher, R., Ndimba, R., Cunningham, C., Martínez-López, W., Schunck, C. & Vandevoorde, C. (2021). An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes. Journal of Visualized Experiments. 25(178). doi: 10.3791/62623.
Lafon-Hughes, L. (2021). El Diario de Salto: Sprays nasales con polisacáridos: ¿barrera física anti-coronavirus?
Capoano CA, Ortiz-Laquintana LA, Rodríguez-Casuriaga R, Schlapp G, Meikle MN, Mulet AP, Crispo M, Benavente R & Geisinger A (2021). SPATS1 (Spermatogenesis-associated, serine-rich 1) is not essential for spermatogenesis and fertility in mouse. PLOS One.
Geisinger A, Rodríguez-Casuriaga R & Benavente R (2021). Transcriptomics of meiosis in the male mouse. Frontiers in Cell and Developmental Biology.
Rodríguez-Casuriaga R & Geisinger A (2021). Contributions of flow cytometry to the molecular study of spermatogenesis in mammals. International Journal of Molecular Sciences.
Geisinger A & Rodríguez-Casuriaga R (2021). Flow Cytometry and Spermatogenesis. Encyclopedia.
2020
Perini, V., Schacke, M., Liddle, P., Vilchez-Larrea, S., Keszenman, D. J. (*) & Lafon-Hughes, L.(*). (2020). PARP Inhibitor Olaparib Causes No Potentiation of the Bleomycin Effect in VERO Cells, Even in the Presence of Pooled ATM, DNA-PK, and LigIV Inhibitors. International Journal of Molecular Sciences. https://www.mdpi.com/1422-0067/21/21/8288/pdf
Trovero MF, Rodríguez-Casuriaga R, Romeo C, Santiñaque FF, François M, Folle GA, Benavente R, Sotelo-Silveira JR & Geisinger A (2020). Revealing stage-specific expression patterns of long noncoding RNAs along mouse spermatogenesis. RNA Biology.
Hernández D, Geisinger A, Trovero MF, Santiñaque FF, Brauer M, Folle GA, Benavente R, & Rodríguez-Casuriaga R (2020). Familial primary ovarian failure associated with a SYCE1 point mutation: Defective meiosis elucidated in humanized mice. Molecular Human Reproduction.
Cancela S, Canclini L, Mourglia-Ettlin G, Hernández P & Merlino A (2020). Neuroprotective effects of novel nitrones: in vitro and in silico studies. European Journal of Pharmacology.
Burgui M, Hernández P, Cabrera M, Cerecetto H, González M, Kartje R, Raimondi A, Oggero M & Bollati M (2020). Identification and characterization of human interferon alpha inhibitors through a WISH cell line based reporter gene assay. Bioorganic Chemistry.
Marizcurrena JJ, Acosta S, Canclini L, Hernández P, Vallés D, Lamparter T & Castro-Sowinski S (2020). A natural occurring bifunctional CPD/6,4-photolyase from the Antarctic bacterium Sphingomonas sp. UV9. Applied Microbiology and Biotechnology.
2019
Schacke, M., Kumar, J., Colwell, N., Hermanson, K., Folle, G. A., Nechaev, S., Dhasarathy, A. & Lafon-Hughes, L. (2019). PARP-1/2 Inhibitor Olaparib Prevents or Partially Reverts EMT Induced by TGF- in NMuMG Cells. International Journal of Molecular Sciences.
Trovero MF & Geisinger A (2019). Long non-coding RNAs and their involvement in testicular pathologies. AnFaMed.
Hernández P, Alem D, Nieves M, Cerecetto H, Gonzalez M, Martinez-Lopez W & Lavaggi ML (2019). Chemosensitizer effect of cisplatin-treated bladder cancer cells by phenazine-5,10-dioxides Environmental Toxicology and Pharmacology.
Pérez F, Varela M, Canclini L, Acosta Deccia S, Martinez-Lopez W, López GV & Hernández, P (2019). Furoxans and tocopherol analogs-furoxan hybrids as anti-cancer agents. Anti-Cancer Drugs.
Ingold M, Colella L, Hernández P, Batthyány C, Tejedor D, Puerta A, García-Tellado F, Padrón JM, Porcal W & López GV (2019). A Focused Library of NO-donors compounds with potent antiproliferative activity based on Green Multicomponent Reactions. ChemMedChem.
Capítulos de libros
Lafon-Hughes, L. (2023). Poli (ADP-ribosa): la molécula que abraza. En: Libro conmemorativo de los 95 años del IIBCE (Ed.: Leo Lagos). pp 72-75.
Alem, D. & Canclini, L. (2023). Historia de una colaboración científica y un descubrimiento inesperado. En: Libro conmemorativo de los 95 años del IIBCE (Ed.: Leo Lagos). pp 76-79.
Geisinger, A & Rodríguez Casuriaga, R. (2023). La meiosis y el complejo sinaptonémico: siete décadas de historia en el IIBCE. En: Libro conmemorativo de los 95 años del IIBCE (Ed.: Leo Lagos). pp 80-83.
Folle, G. (2023). Investigaciones sobre la gonileptidina. En: Libro conmemorativo de los 95 años del IIBCE (Ed.: Leo Lagos). pp 84-86.
Di Tomaso MV & Martínez-López, W. (2023). Luces y sombras sobre las radiaciones ionizantes. en busca de nuevos blancos moleculares para minimizar sus efectos secundarios. En: Libro conmemorativo de los 95 años del IIBCE (Ed.: Leo Lagos). pp 88-91.
Di Tomaso MV (2023). Colaboración para enfrentar la brecha de género en ciencia. En: Libro conmemorativo de los 95 años del IIBCE (Ed.: Leo Lagos). pp 46-48.
Kumar ARK, Martínez-López W & Saraswathy R (2022). Overall Thymoquinone pharmacological properties and its use as an anticancer agent. En: Biotechnology for Toxic Remediation and Sustainability. Biotechnology for Toxic Remediation and Environmental Sustainability. (Ed.: Taylor and Francis Group). pp 227-251.
Martínez-López, W. & Prakash Hande, M. (2019). Health Effects of Exposure to Ionizing Radiation. En: Advanced Security and Safeguarding in the Nuclear Power Industry. 1st Edition. Impacts of Radiation and Disaster Planning in the Modern World.
Pereira AC, Cuttinella M, Di Tomaso MV, Rehermann MI, Castelló ME & Varela Belloso G. (2019). Concepciones sobre Naturaleza de la Ciencia en Docentes de Educación Primaria en Uruguay En: Enseñanza y Aprendizaje de las Ciencias en Debate Vol 1: Didáctica de las Ciencias. Género e Inclusión Educativa en STEM (Ed.: Beatriz Macedo B, Silveira S, Meziat D, García Astete M, Bengochea L, Universidad de Alcalá, Servicio de Publicaciones Alcalá de Henares, España). pp 637-346.